BACKGROUND: High-grade B-cell lymphoma with rearrangements of MYC and BCL2 and/or BCL6, known as double-hit lymphoma, is a highly aggressive malignancy with poor outcomes after standard chemoimmunotherapy. We aimed to study whether the addition of the BCL2-inhibitor venetoclax to chemoimmunotherapy in patients with double-hit lymphoma resulted in superior efficacy compared with chemotherapy alone.

Whole brain radiotherapy (WBRT) prolongs survival for patients with brain metastases but produces persistent oxidative injury to the brain and long-term neuropsychiatric sequelae, for which no approved neuroprotective therapies exist. Here, we show that a single course of WBRT produces chronic oxidative stress in mice that persists for at least one year, equivalent to decades in humans, and selectively injures the hippocampus, causing cognitive decline and depressive-like behavior. Daily...

Radiation-associated cardiac disease frequently affects cancer patients when radiation fields overlap the heart, but relationships between cardiac substructure dose and specific cardiac events remain poorly understood. This study examined associations between radiation dose to cardiac substructures and adverse cardiac events in thoracic malignancy patients. We retrospectively analyzed 94 patients with lung, esophageal and breast cancers who received radiation therapy. Radiation-induced adverse...

CONCLUSIONS: This study presents a novel role for selective superoxide dismutase mimetics, such as RUC, in protecting against CTI-induced cardiovascular toxicities. As RUC dismutates superoxide, the results suggest superoxide plays a key part in the modulation of mitochondrial oxidative phosphorylation, activation of the canonical TGF-β/Smad pathway, and ionizing radiation cardiovascular side effects. These findings suggest an association between RUC treatment and TGF-β pathway antagonism that...