Radiation-associated cardiac disease frequently affects cancer patients when radiation fields overlap the heart, but relationships between cardiac substructure dose and specific cardiac events remain poorly understood. This study examined associations between radiation dose to cardiac substructures and adverse cardiac events in thoracic malignancy patients. We retrospectively analyzed 94 patients with lung, esophageal and breast cancers who received radiation therapy. Radiation-induced adverse...

CONCLUSIONS: This study presents a novel role for selective superoxide dismutase mimetics, such as RUC, in protecting against CTI-induced cardiovascular toxicities. As RUC dismutates superoxide, the results suggest superoxide plays a key part in the modulation of mitochondrial oxidative phosphorylation, activation of the canonical TGF-β/Smad pathway, and ionizing radiation cardiovascular side effects. These findings suggest an association between RUC treatment and TGF-β pathway antagonism that...

Pharmacological ascorbate (IV delivery, to plasma levels ≈ 15-20 mM) has been shown to be selectively toxic to cancer vs. normal cells as well as inducing radio-chemo-sensitization in non-small cell lung cancer (NSCLC) via increased generation of hydrogen peroxide (H(2)O(2)) and increased intracellular redox-active iron (Fe^(2+)). The current study shows that 24 h pretreatment with an FDA-approved iron-oxide nanoparticle, Ferumoxytol (FMX), enhances the toxicity of P-AscH^(-) in human NSCLC...

Small cell lung cancer (SCLC) has a 6% 5-year overall survival rate. C-X-C chemokine receptor 4 (CXCR4) is an attractive target for theranostic agents, is highly expressed in SCLCs, and can be targeted with pentixather using the theranostic pair 212Pb/203Pb. The hypothesis that 212Pb/203Pb-pentixather can be used safely and effectively for imaging and therapy in SCLC in xenograft models was tested. SPECT-CT imaging and biodistribution studies of tumor-bearing mice injected with 203Pb-pentixather...

CONCLUSIONS: Given the increasing threat of emerging and re-emerging infectious diseases, this framework reinforces the need to prioritize equitable approaches in responding to infectious disease public health emergencies to minimize health consequences, particularly among vulnerable populations. This framework is designed as a practical tool for public health professionals to guide major aspects of an epidemic response, ensuring thorough and equitable implementation of response efforts.